ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo.

2023年10月1日 · This review focuses on the structure and biological functions of Arf6 and its effectors, summarizes the recent development of the relative inhibitors of Arf6 activation in cancer treatment and speculates on the future of developing Arf6 inhibitors based on drug sensitization.

2024年12月24日 · ARF6 (ARF GTPase 6) is a Protein Coding gene. Diseases associated with ARF6 include Cholera and Fetal Akinesia Deformation Sequence 4 . Among its related pathways are Vesicle-mediated transport and Rab regulation of trafficking .

2006年5月1日 · ARF6 localizes to the plasma membrane and endosomal compartments, in which it regulates clathrin-dependent endocytic membrane trafficking, as well as the trafficking and sorting of...

Arf6 influences membrane trafficking and the actin cytoskeleton at the plasma membrane (PM). The goal of this review is to summarize these recent findings and provide a cellular context for understanding Arf6 function.

2023年2月22日 · ADP ribosylation factor 6 (Arf6) is a small GTPase that promotes the assembly of actin necessary for CME. In its absence, growth factor signaling is greatly diminished, which has been shown to ameliorate pathological signaling input in diseased vasculature.

2019年5月5日 · Arf6 is used for the phagocytosis of pathogens and can be directly or indirectly targeted by various pathogens to block phagocytosis or induce the uptake of intracellular pathogens. Arf6 is also used in the signaling of Toll-like receptors and in …

2016年6月23日 · Nature Communications - The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes...

2021年8月20日 · The data suggest that Arf6 regulates energy metabolism, which may contribute to impaired phagocytosis, ROS production, and apoptosis in PMN-Arf6 cKO. This study provides new information on the functions and the inflammatory pathways influenced by Arf6 in PMNs.

ARF6, also known as ADP-ribosylation factor 6, is a small G protein involved in trafficking. It plays a crucial role in controlling lipid assembly to AP-2 and regulating vesicular transport by affecting membrane lipid composition and actin organization.