2021年8月1日 · ALK4, ALK5, or ALK7 antagonism pivots around small-molecule inhibitors. The small-molecule inhibitors work by occupying the adenosine triphosphate binding site of the ALK kinase, thereby obstructing its phosphorylation of Smad2/3 [ 45 ].

2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.

ALK4 Function. ALK4 (ACVR1B) is a versatile receptor that has a critical role in development. In Xenopus, ALK4 activates both sides of the developmental pathway: the TGFβ-driven left side with the ligands Xnrl and derriere and the BMP-driven right side with the ligand Vgl .

Antisense oligonucleotides (AONs) were designed specifically to block the function of ALK4, a key receptor for the MSTN/activin pathway in skeletal muscle. AON-induced exon skipping resulted in specific Alk4 down-regulation, inhibition of MSTN activity, and increased myoblast differentiation in vitro Unexpectedly, a marked decrease in muscle ...

The truncated form of ALK4 functions as a dominant negative inhibitor of activin signaling and eliminates the growth suppression induced by activin , while the overexpression of wild-type ALK4 restores the anti-proliferative activity of activin in human pituitary tumor cells .

2019年5月3日 · The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an axonal injury.

2025年2月8日 · ALK4 is an important profibrotic signaling molecule in the post-MI CF. Haplodeficiency of ALK4 significantly improved LV function and survival rate by attenuating CF in vivo, ameliorated. ALK4 is expressed in male germ cells and Sertoli cells.

The activation of activin receptor-like kinase 4 (ALK4) signaling plays a pivotal role in the pressure-overloaded heart, and haplodeficiency of ALK4 can alleviate cardiac fibrosis secondary to myocardial infarction and preserve cardiac function ...

2004年4月15日 · We report here that similar to effects of ectopic TGF betas, right-side expression of constitutively active activin-like kinase (ALK) 4 results in LR organ reversals as well as altered Pitx2 expression in the lateral plate mesoderm.

2020年1月1日 · Göngrich et al. show that the activin receptor ALK4 is a key regulator of the specification of somatostatin interneurons. They find that intrinsic transcriptional programs interact with extracellular signals present in the environment of MGE cells to …