2024年12月24日 · ABCG1 (ATP Binding Cassette Subfamily G Member 1) is a Protein Coding gene. Diseases associated with ABCG1 include Tangier Disease and Pulmonary Alveolar Proteinosis. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and NR1H2 and NR1H3-mediated signaling.

2015年2月27日 · ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of...

ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, demonstrating its direct role of ABCG1 in cellular cholesterol transport; ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles

2022年2月1日 · ATP-binding cassette protein A1 (ABCA1) and G1 (ABCG1) are important in eliminating excess cholesterol from cells including macrophages and forming high-density lipoprotein, which contributes to the prevention and regression of atherosclerosis.

ABCG1 is the founding member of the ABCG family that consists of half-size ABC proteins with a high sequence similarity and expression pattern to ABCA1 [100]. ABCG1 can function as a homodimer [101]. The human ABCG1 gene maps to chromosome 21q.22.3 [102,103].

2017年2月6日 · Our findings suggest that the actin cytoskeleton plays a critical role in the plasma membrane localization of ABCG1. The ATP-binding cassette (ABC) sub-family G member 1 (ABCG1) is a...

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL.

2024年12月25日 · ABCG1 regulates pulmonary surfactant metabolism in mice and in humans. ABCG1-deficient mice have been shown to accumulate surfactant, lipid-laden macrophages and lamellar bodies of epithelial type 2 pneumocytes, B1-lymphocytes, and immunoglobulins .

2022年1月25日 · The cryo-EM structure of human ABCG1 reported by Xu et al. reveals an ABCG1-driven cholesterol transport cycle initiated by sphingomyelin-assisted cholesterol recruitment and accomplished with cholesterol sequestration by the acceptors.

In this chapter, we summarize the roles of ABCA1 and ABCG1 in maintaining cellular cholesterol homoeostasis and discuss the underlying mechanisms by which they mediate cholesterol export.