MiR-101 regulates ribosomal protein L11 (RPL11) localization and its interaction with MDM2pProto-oncogene (MDM2) by inhibiting the ubiquitin-specific peptidase 47 (USP47)-induced deubiquitylation of RPL11. MiR-101 was found to bind directly to the 3′-UTR region of the USP47 mRNA and inhibit its expression . Cullin 4B (CUL4B) encodes a ...

2024年12月25日 · MIR101-1 (MicroRNA 101-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR101-1 include Lung Cancer and Adrenal Cortical Adenocarcinoma. Among its related pathways is Alzheimer's disease and miRNA effects. ... Control Lentivectors and Lentiviruses with GFP, RFP, and Luciferase also available.

2018年11月15日 · In this review, we aim to summarize the function of miR-101 in different biological processes by figuring out the underlying target gene networks and explore its potential role as a biomarker in diverse neoplasms, which will provide a brand-new insight in molecular targeting cancer treatment.

In this review, we will focus on the function of miR-101 in cancer-related biological processes, including proliferation, apoptosis, angiogenesis, drug resistance, invasion and metastasis, and explore the potential role of miR-101 as a biomarker in various neoplasms, which might offer a novel guidance in molecular targeting cancer treatment.

miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739) [1] and mouse . [2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046).

2022年11月28日 · MiR-101 has key roles in cancer initiation, progression, and metastasis as miR-101 is a critical regulator of gene expression by binding to complementary sequences in the 3′-UTR of mRNAs to target them for degradation or prevent the target gene translation.

miR-101可同时靶向CAFs与肿瘤细胞，是一种高效的抗肿瘤小分子RNA。 本研究不仅深化了人们对miR-101的转录调控网络及生物学功能的认识，并且为肝癌的防治提供了新靶点。

miR-101是一种微小RNA,长度为21个核苷酸,由pre-mir-101-1和pre-mir-101-2加工生成,在不同的物种之间均表现为高度保守的表达.miR-101在多种肿瘤组织中表达下调,包括肺癌,胃癌,肝癌,结直肠癌,卵巢癌和骨肉瘤等,提示其在肿瘤的发生和发展中发挥重要作用.文章对近5年国内外 ...

2021年10月20日 · miR-101-3p可用于治疗多种肿瘤的治疗，但是它的抗肿瘤机制仍然未知，并且其用于体内肿瘤治疗的确切策略也尚不可知。 本研究探究了miR-101-3p对肿瘤细胞的抑制机制，并开发了相应的体内治疗纳米药物。 本文于2021年6月发表在《Redox Biology》IF：11.799期刊上。 技术路线： 主要的实验结果： 1、miR-101-3p的表达在肿瘤细胞系和肿瘤组织中下降. 作者检测了6株肺癌细胞系A549，L78，NCI–H460，GLC-82，SPC-A1，PC9和一株人上皮细胞 …

2025年3月19日 · We found that miR-101-3p reduced the luciferase activity of the 3′UTRwt but not the 3′UTRmut (n = 3, p < 0.05, Fig. 3B), suggesting that Birc5 is a direct functional target of miR-101-3p and that miR-101-3p can bind to the Birc5 3′-UTR site to inhibit Birc5 expression, exerting its anticancer effects. To further validate that the target ...