2024年12月25日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying …

2020年6月7日 · We show that transient ZSCAN4 induction for just 2 days increases CSC frequency both in vitro and in vivo and leads to upregulation of pluripotency and CSC factors.

2024年12月20日 · Zscan4 exhibits burst expression in 2C embryos and 2C-like cells. Here, we show that Zscan4 mediates chromatin remodeling to promote the chromatin accessibility for …

2010年3月24日 · The transient Zscan4-positive state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis-specific homologous recombination …

ZSCAN4能够调控早期胚胎发育过程,在合子基因组激活(zygotic genome activation, ZGA)期间通过促进DNA损伤修复和纠正染色体异常,以维持植入前胚胎的基因组和染色体完整性。

2020年3月20日 · One of the 2C-specific transcripts activated during the minor ZGA is Zscan4 (Zinc finger and SCAN domain–containing 4), encoded by a highly homologous six-gene …

2007年7月15日 · Utilizing DNA microarray data, we looked for genes that are expressed only during ZGA and found Zscan4, whose expression is restricted to late 2-cell stage embryos. …

2025年2月8日 · The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular …

2007年7月15日 · Zscan4 is the first example of a gene that is expressed exclusively in late 2-cell embryos and embryonic stem (ES) cells. Loss-of-function study by siRNA technology indicates …

2016年4月12日 · If Zscan4 is activated for repair by sensing shortened telomeres, the upregulation of Zscan4 should be followed by shortening of the cell cycle after the recovery of …