2023年3月21日 · 使用 Vgat-Cre 小鼠，科研工作者可特异性标记γ-氨基丁酸（GABA）能神经元，进而通过 光遗传学 、 化学遗传学 等操控手段以及 钙成像 、 光电极 等记录手段特异性探究单一脑区内 GABA 能神经元的功能。

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene. [5] The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/ polyamine transporter family II. [5]

Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In the present study, we showed that proteoliposomes containing purified VGAT transport β-alanine using Δψ as a driving force. VGAT also facilitates Cl ...

This vesicular GABA transporter (VGAT), the first vesicular amino acid transporter to be molecularly identified, differs in structure from previously cloned vesicular neurotransmitter transporters and defines a novel gene family. Here we use antibodies specific for N- and C-terminal epitopes of VGAT to localize the protein in the rat CNS.

已经鉴定出一种独特的蛋白质，水泡GABA转运蛋白（VGAT），在其胞吐释放之前将GABA累积到突触前小泡中。 VGAT的功能及其分布在成人中已得到很好的定义，但是它对未成熟大脑中假定的GABA能神经末梢的短暂兴奋作用的贡献以及在假定的谷氨酸能神经末梢中的潜在 ...

2024年10月29日 · Vgat-cre和Vglut2-cre是两种用于研究特定神经元类型的遗传工具鼠。 Vgat-cre主要针对GABA能神经元，而Vglut2-cre则关注谷氨酸能神经元。 Vgat-cre的遗传背景是C57BL/6J，其品系类型为基因敲入，相关基因是Slc32a1。

2006年6月1日 · In the LH, the BDA-labeled varicosities were immunopositive (+) for VAChT ( approximately 10%), VGluT2 ( approximately 25%), or VGAT ( approximately 50%), revealing an important influence of newly identified glutamatergic together with GABAergic BF inputs.

2024年11月25日 · 囊泡γ-氨基丁酸转运体VGAT负责在中央神经系统的突触小泡中摄取和储存GABA和甘氨酸。 因此，它常被称为囊泡抑制性氨基酸转运体VIAAT。 它与质膜转运体不同，因为它是由囊泡膜上的质子电化学梯度驱动的。 到目前为止，只知道有一种异构体。

2010年12月30日 · The vesicular GABA transporter (VGAT) loads GABA and glycine from the neuronal cytoplasm into synaptic vesicles. To address functional importance of VGAT during embryonic development, we generated global VGAT knockout mice and analyzed them.

The vesicular transmitter transporters VGLUT, VGAT, VMAT2 and VAChT, define phenotype and physiological properties of neuronal subtypes. VGLUTs concentrate the excitatory amino acid glutamate, VGAT the inhibitory amino acid GABA, VMAT2 monoamines, ...