The highly homologous protein VGLUT2, also initially characterized as a phosphate transporter and named differentiation-associated Na + -dependent inorganic phosphate transporter (DNPi), has a nearly complementary pattern of expression with one of the two proteins present in all established glutamatergic neurons.

Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

2023年5月11日 · In the mammalian central nervous systems, three vesicular glutamate transporters (VGLUT1, VGLUT2 and VGLUT3) are responsible for filling the synaptic vesicles of excitatory neurons with...

2021年6月2日 · Here we show that the subpopulation of midbrain dopaminergic neurons that express the vesicular glutamate transporter 2 (VGLUT2) are more resilient to rotenone-induced neurodegeneration. Rotenone also upregulates VGLUT2 more broadly in the midbrain, suggesting that VGLUT2 expression generally confers increased resilience to rotenone.

In this review, a new homology model for VGLUT2 based on DgoT has been developed and used to conduct docking experiments to identify and differentiate residues and binding orientations involved in ligand interactions. This review describes small molecule-ligand interactions including docking using a VGLUT2 homology model derived from DgoT.

2011年3月18日 · Recent work in knockout mice suggests: first, that vesicular glutamate transporter 2 (VGLUT2) in dopamine neurons regulates behavioural activation induced by psychostimulant drugs; second, that...

Two VGLUT isoforms, VGLUT1 and VGLUT2, are known to characterize complementary distributions of glutamatergic neurons in the rodent brain, which suggests that they are each responsible for unique circuits of excitatory transmission.

2006年11月15日 · Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem.

2020年5月8日 · Vesicular glutamate transporter-2 (VGLUT2)-expressing neurons in the VNC have a crucial role in vestibular system-related thermoregulation. Our experiments first...

2020年5月30日 · VGLUTs: Markers for Glutamatergic Transmission VGLUT1 and VGLUT2 are expressed in distinct and complementary subsets of neurons in the CNS that display differences in release probability [36, 39]. VGLUT1 is the most abundant subtype in the CNS [47].