2020年7月11日 · U0126 protects PC12 cells against H2O2-induced cell death. Western blot of ERK phosphorylation demonstrates that the MEK inhibitors U0126, GSK1120212 and Pimasertib are effective in blocking ERK phosphorylation under complete media, while U0124 results in slight ERK inhibition compared to DMSO control.

U0126即1,4-Diamino-2,3-dicyano-1,4-bis (o-aminophenylmercapto)butadiene，是一种常用的MAPKK抑制剂，即MAPK kinase抑制剂或MEK1/2抑制剂。 U0126可以通透细胞，选择性抑制MEK1/2，从而抑制MAP kinase (Erk1/2即p44/42 MAPK)的磷酸化和激活。

2020年7月7日 · U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.

U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR)-p70 (S6K) pathways.

2025年3月7日 · U0126即1,4-Diamino-2,3-dicyano-1,4-bis (o-aminophenylmercapto)butadiene，是一种常用的MAPKK抑制剂，即MAPK kinase抑制剂或MEK1/2抑制剂。 U0126可以通透细胞，选择性抑制MEK1/2，从而抑制MAP kinase (Erk1/2即p44/42 MAPK)的磷酸化和激活。

U0126是一种选择性、非竞争性MAPK激酶抑制剂，作用于MEK1和MEK2，IC50分别是70 nM和60 nM，比PD 98059的抑制活性高100倍左右，而对其他MAPK激酶如PKC、Ab1、Raf、MEKK、ERK和JNK等没有或微弱抑制作用。

If your scan tool can access fault codes and the only one you retrieve from other modules is the U0126, try to access the steering angle system module. If you can access codes from the SAS module, then the U0126 code is either intermittent or a memory code.

5 天之前 · U0126 has been shown to be a highly selective inhibitor of MEK 1 and MEK 2. When compared with PD98059 #9900, U0126 shows a significantly higher affinity for MEK1. U0126 and PD98059 bind to this enzyme in a mutually exclusive fashion suggesting that they share a common binding site (5).

U0126-EtOH (U0126 Ethanol)是非ATP竞争性的MEK1/2抑制剂，IC 50 值为 70 nM和60 nM，对其它的MAPKKs没有影响，具有抗病毒活性。 U0126最初被鉴定为AP-1转录激活的抑制剂，可抑制含有AP-1反应元件的内源性启动子。

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