Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) [5] is a protein that in humans is encoded by the TACSTD2 gene. [6] [7] [8] This intronless gene is located at the short arm of chromosome 1 (1p32.1). [9] It encodes a carcinoma-associated antigen defined by the monoclonal ...

2023年3月13日 · In our work, we briefly summarize the various characteristics of cancer cells overexpressing Trop-2, the pre-clinical activities of specific inhibitors, and the role of anti-Trop-2 therapy in current clinical practice.

2025年3月3日 · What are Trop-2 antibody-drug conjugates? Most breast cancers have cells that express the protein Trop-2. Trop-2 antibody-drug conjugate drugs combine a Trop-2 antibody and a chemotherapy drug. This combination allows the targeted delivery of the chemotherapy to cancer cells that express Trop-2.

TROP2 全称为人滋养细胞表面糖蛋白抗原2，是由染色体1P32区域的 Tacstd2基因 编码表达的细胞表面糖蛋白，与上皮黏附分子 Epcam 有较高的结构序列相似性，同源性达49%。 TROP2属于跨膜蛋白，N-端为胞外域（Trop2EC），该胞外域通过一个单向跨膜螺旋（TM)与由26氨基酸残基构成的疏水性多肽的胞内短尾（Trop2IC）连接，从而固定于胞膜 。 Trop-2结构（Oncotarget, …

2025年2月8日 · TROP2, or trophoblast cell surface antigen 2, is significant in cancer biology due to its overexpression in various epithelial cancers. This transmembrane glycoprotein, encoded by the TACSTD2 gene, is involved in cellular processes that contribute to tumorigenesis.

2022年3月2日 · On April 23, 2020, Trodelvy (Sacituzumab govitecan), the first ADC drug targeting Trop-2, received accelerated approval from the FDA for the treatment of unresectable locally advanced or metastatic TNBC. This demonstrates the …

2022年2月25日 · This article provides an overview of antibody-drug conjugates for the treatment of solid tumors and examines emerging evidence demonstrating Trop-2 as a potential target in breast and lung...

2018年6月22日 · TROP-2 is a glycoprotein first described as a surface marker of trophoblast cells, but subsequently shown to be increased in many solid cancers, with lower expression in certain normal tissues. It regulates cancer growth, invasion and spread by several signaling pathways, and has a role in stem cell biology and other diseases.

2024年5月17日 · Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed promising efficacy in treating diverse solid tumors, especially breast cancer and urothelial carcinoma.

2025年3月6日 · Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy. This progress also holds promise for the treatment of small cell lung cancer (SCLC) as anti-Trop-2 therapy appears to have a safe and effective clinical activity in metastatic SCLC patients. …