The biology of TREM receptors - Nature Reviews Immunology
2023年2月7日 · In this Review, I detail the genomic organization, structure and signalling mechanisms of TREMs, and extensively discuss the functions of TREM1 and TREM2, which …
TREM1 Gene - GeneCards | TREM1 Protein | TREM1 Antibody
2024年12月25日 · TREM1 (Triggering Receptor Expressed On Myeloid Cells 1) is a Protein Coding gene. Diseases associated with TREM1 include Maxillary Sinusitis and Pneumonia. …
TREM-1: intracellular signaling pathways and interaction with
TREM-1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that …
TREM1: Activation, signaling, cancer and therapy - PubMed
TREM1-deficiency or blockade provide protection against tumors and reverse the resistance to anti-PD-1/PD-L1 therapy and arginine-deprivation therapy in preclinical models. Here, we first …
TREM-1 multimerization is essential for its activation on
2018年3月22日 · Here, we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+ release, reactive oxygen species, and cytokine production correlate with …
TREM1: Activation, signaling, cancer and therapy
2024年6月1日 · Activated TREM1 initiates an array of downstream signaling pathways that ultimately result in the production of pro-inflammatory cytokines and chemokines, whereby it …
TREM1 disrupts myeloid bioenergetics and cognitive function in …
2024年3月27日 · In vitro, Trem1 -deficient microglia are resistant to amyloid-β 42 oligomer-induced bioenergetic changes, suggesting that amyloid-β 42 oligomer stimulation disrupts …
TREM1 triggering receptor expressed on myeloid cells 1 [ (human)]
2025年2月19日 · Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages. Molecular and immunological …
TREM-1 and TREM-2 as therapeutic targets: clinical challenges …
Triggering receptor expressed on myeloid cells 1 (TREM-1) plays a pivotal role in human health and disease (1 – 6). Despite promising preclinical data and safety in humans, the first clinical …
The biology of TREM receptors - PMC
Triggering receptors expressed on myeloid cells (TREMs) are a family of cell-surface receptors expressed broadly on myeloid cells. The first TREM identified, TREM1, was characterized as …
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