TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions throughout the body. In a context- and cell type–specific manner, TOLLIP can function as an inhibitor of …

2024年3月25日 · Toll-interacting protein (TOLLIP) prevents inflammation and lipid accumulation in alveolar macrophages to limit integrated stress response activation, macrophage necrosis and …

2024年12月25日 · TOLLIP (Toll Interacting Protein) is a Protein Coding gene. Diseases associated with TOLLIP include Lymphoproliferative Syndrome, X-Linked, 1 and Idiopathic …

2012年2月1日 · The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane …

2016年12月7日 · As brain inflammation is known to contribute to Parkinson's disease, Tollip may be a potential target for neuroprotection. Altogether, these findings highlight a critical role of …

2000年5月10日 · Here we show that, before IL-1β treatment, Tollip is present in a complex with IRAK, and that recruitment of Tollip–IRAK complexes to the activated receptor complex occurs …

2020年10月31日 · They found that TOLLIP expression is downregulated in fibroblasts from patients with ALS in response to LPS-induced inflammation, indicating that TOLLIP may play a …

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein involved in multiple intracellular signaling pathways. It plays a key role in mediating inflammatory intracellular …

2016年12月7日 · We report an unexpectedly high Tollip immunostaining in dopaminergic neurons of the mice brain. Second, intra-nigral injection of LPS led to increased susceptibility to …

Results: Tollip interacts with Smad7 and TGF-β receptors and negatively regulates cellular signaling and function of TGF-β. Conclusion: Tollip modulates intracellular trafficking and …