Recent advances in urea- and thiourea-containing compounds: …
Here, we review the status of urea- and thiourea-containing approved drugs, including antitumor, chemotherapeutic agents, and central nervous system (CNS) drugs.
Advancement and recent trends in seeking less toxic and more …
2022年2月8日 · The finding of potent anticancer agents with low toxicity and high selectivity has remained valuable for human health. Thiourea derivatives are the most significant organic compounds with integral and typical characteristics of numerous varieties of natural products and pharmaceutical agents.
Thiourea - an overview | ScienceDirect Topics
Thioureas are commercial chemical molecules that have been recently investigated to identify novel H2 S donors [71]. Among them, N-phenylthiourea (PTU) and N,N’-diphenylthiourea (DPTU) showed long-lasting H 2 S release in cell-free amperometric tests and …
Thiourea - Wikipedia
Thiourea (/ ˌ θ aɪ. oʊ j ʊəˈr iː. ə,-ˈ jʊər i-/) [2] [3] [4] is an organosulfur compound with the formula SC(NH 2) 2 and the structure H 2 N−C(=S)−NH 2. It is structurally similar to urea ( H 2 N−C(=O)−NH 2 ), except that the oxygen atom is replaced by a sulfur atom (as implied by the thio- prefix); however, the properties ...
Biological Applications of Thiourea Derivatives: Detailed Review
2024年5月31日 · Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties.
Recent advances in urea- and thiourea-containing compounds: focus on ...
Herein, we provide an overview of the state-of-the-art of urea and thiourea-containing pharmaceuticals. We also review the diverse approaches pursued for (thio)urea bioisosteric replacements in medicinal chemistry applications.
Urea and Thiourea Derivatives in Modern Drug Discovery and
2023年5月10日 · Metformin (biguanide) and glimepiride (sulfonylurea) are both drugs that are derivatives of urea, and they are widely used as first-line drugs for the treatment of type 2 diabetes mellitus. Palmatine has been previously reported …
Thiourea - DrugBank Online
Drug Drug Description; Metiamide: Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. Noxytiolin: Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions.
Recent trends in chemistry, structure, and various applications of 1 ...
Thiourea derivatives are used as ligands in metal complexes, their fascinating coordination chemistry along with their derivatives finds a special place in the mind of researchers due to their vast potential applications in various fields.
Design, synthesis, characterization, and biological evaluation of ...
2021年1月14日 · Addressed herein a series of thioureas starting from various amines and nicotinic acid have been synthesized. Notably, thiourea based scaffolds are increasingly employed in medicinal chemistry...