T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that cause T h 17s to actually inhibit T reg differentiation. [1] . However, T h 17s are developmentally distinct from T h 1 and T h 2 lineages.

Recent data in humans and mice suggest that Th17 cells play an important role in the pathogenesis of a diverse group of immune-mediated diseases, including psoriasis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and asthma. Initial reports also propose a role for Th17 cells in tumorigenesis and transplant rejection.

Learn more about T helper 17 cells (Th17 cells), including T helper 17 cell activation, differentiation, and function.

2023年1月3日 · In this Review, we discuss the heterogeneity of T H 17 cells and the role of this heterogeneity in diverse functions of T H 17 cells from homeostasis to tissue inflammation.

Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are involved in the pathogenesis of many autoimmune diseases. The receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues.

Discover T helper type 17 (Th17) Cell Markers CD4, IL-6, and more with our interactive tool. Browse validated antibodies for Flow, IHC, ICC/IF, and WB+.

2009年8月27日 · Type 17 helper T cells (Th17) — a third class of T cells — and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and ...

2021年9月27日 · In 2005, two independent papers described a third lineage of CD4 + T H cells that produce IL-17, referred to hereafter as T H 17 cells. Although T H 1 cells were historically linked to...

2022年12月15日 · Th17 cells produce inflammatory cytokines like IL-17 and TNF-alpha. As part of a series on immune health, this post goes over the Th17 response, associated diseases, and complementary approaches — including lifestyle, food, and supplement choices — that may help keep the immune system in good health.

Th17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells have been found in various human cancers.