TRPM7 - Wikipedia
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name. TRPs, mammalian homologs of the …
Structural mechanisms of TRPM7 activation and inhibition
2023年5月8日 · Here we use cryo-EM, functional analysis, and molecular dynamics simulations to uncover two distinct structural mechanisms of TRPM7 activation by a gain-of-function mutation …
TRPM7 Gene - GeneCards | TRPM7 Protein | TRPM7 Antibody
2024年12月25日 · TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7) is a Protein Coding gene. Diseases associated with TRPM7 include Amyotrophic Lateral …
TRPM channels in health and disease - Nature Reviews Nephrology
2023年10月18日 · TRPM6 and TRPM7 are bifunctional kinase-coupled channels that control cellular and body homeostasis of Zn 2+, Mg 2+ and Ca 2+. TRPM4 and TRPM5 are Ca 2+ …
TRPM7 and its role in neurodegenerative diseases - PMC
In the present review we focus on the emerging role of transient potential melastatin-7 (TRPM7) channel in not only regulating Ca 2+ and Mg 2+ homeostasis necessary for biological …
The TRPM7 channel reprograms cellular glycolysis to drive
2023年3月6日 · RNA-seq, metabolomics and genetic assay revealed that the TRPM7 channel regulated cellular glycolysis. Deletion of TRPM7 suppressed cancer cell glycolysis and …
TRPM7, Magnesium, and Signaling - PubMed
2019年4月16日 · In this review we focus on TRPM7 and its association with growth factors, RTKs, and downstream kinase signaling. We also highlight how interplay between TRPM7, Mg 2+ …
TRPM7 transient receptor potential cation channel subfamily M …
2025年2月8日 · TRPM7 alpha-kinase modulates inflammatory signaling by aldosterone in a TRPM7 channel/ Mg2+-independent manner. TRPM7 is one of the important nonglutamate …
TRPM7 - PubMed
With its prominent role in cellular and systemic magnesium homeostasis, TRPM7 emerges as a key player in embryonic development, global ischemia, cardiovascular disease, and cancer. …
The kinase activity of the channel-kinase protein TRPM7 regulates ...
The channel-kinase transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein with ion channel and kinase domains. The kinase activity of TRPM7 has been linked to the …
TRPM7 kinase activity induces amyloid-β degradation to ... - Science
2023年7月11日 · Altered abundance or activity of the dual-function transient receptor potential melastatin-like 7 (TRPM7) protein is implicated in neurodegenerative disorders, including …
TRPM7 channel activity promotes the pathogenesis of abdominal …
2025年2月14日 · Here we show that global or vascular smooth muscle cell (VSMC)-specific transient receptor potential melastatin 7 (TRPM7) knockout in mice prevented AAA formation, …
Modulators of TRPM7 and its potential as a drug target for …
2022年1月1日 · TRPM7 is a non-selective divalent cation channel with an alpha-kinase domain. Corresponding with its broad expression, TRPM7 has a role in a wide range of cell functions, …
Structural mechanisms of TRPM7 activation and inhibition
The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, …
TRPM7 Is Required for Normal Synapse Density, Learning, and …
2018年6月19日 · Here, we show that TRPM7 knockdown in hippocampal neurons reduces structural synapse density. The synapse density is rescued by the α-kinase domain in the C …
Development, Pathogenesis, and Regeneration of the …
Sox9 deletion resulted in downregulation of ECM-related genes Col2a1, Col11a1, Col9a2, and ion channel-encoding genes Trpm4, Trpm7 and Piezo2, as well as upregulation of matrix …
The Regulation of Neuro-immune System by Pi (Parasympathetic …
2024年7月31日 · Additionally, the impact of leptin is mediated by Trpm7 (transient receptor potential melastatin) channels in CB glomus cells (Yeung et al. 2021), which are extensively …
TRPM7 is an essential regulator for volume-sensitive outwardly ...
2021年5月20日 · TRPM7 exerts the facilitating action on VSOR activity first by enhancing molecular expression of LRRC8A mRNA through the mediation of steady-state Ca2+ influx …
Assessing the impact of climate policy on energy security in …
2024年1月1日 · TRPM7 deficiency suppresses cell proliferation, migration, and invasion in human colorectal cancer via regulation of epithelial-mesenchymal transition
Forensic and Clinical Forensic Autopsy - Academia.edu
Forensic Science, Medicine, and Pathology, 2008. A study was undertaken of 629 cases autopsied at Forensic Science SA, Adelaide, Australia over a 10-year period from 1994 to …