Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. [5] It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. [6]

Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity.

2024年12月25日 · TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Legionnaire Disease and Melioidosis. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

2017年11月20日 · TLR5 is known to specifically sense and recognize flagellin, the major structural protein of bacterial flagella. 2 It is conceivable that the immune system is equipped with TLR5 for the...

Establishing bacterial flagellin-recognizing toll-like receptor 5 (TLR5) as a novel link between gut microbiota composition, adipose tissue inflammation, and obesity. Flagellin activated TLR5 protein in non-small cell lung cancer cell lines and initiate downstream signaling pathways.

2017年1月23日 · TLR5 is expressed in lung and intestinal epithelial cells, human endometrium, bladder, granulosa cells leukocytes, adipocytes, and some cancer cells, among others. Its signalling is triggered...

TLR5 is a receptor for flagellin, the major structural protein of the flagella of Gram-negative bacteria. You might find these chapters and articles relevant to this topic. Dana J Philpott, ... Philippe J Sansonetti, in Current Opinion in Immunology, 2001.

TLR5 is a type I transmembrane glycoprotein composed of 858 amino acids (aa) in humans and 859 aa in mice with a large extracellular domain, a transmembrane domain, and intracellular domain (Andersen-Nissen et al. 2007).

2021年2月3日 · Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease. Wang R, et al. J Immunol, 2012 Sep 1. PMID 22855713, Free PMC Article. The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens.

Cell Mol Immunol. 2017 Dec;14 (12):1017-1019. doi: 10.1038/cmi.2017.122. Epub 2017 Nov 20. 1 Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.