The TET2 gene provides instructions for making a protein whose function is unknown. Based on the function of similar proteins, researchers believe the TET2 protein is involved in regulating …

2024年12月25日 · TET2 (Tet Methylcytosine Dioxygenase 2) is a Protein Coding gene. Diseases associated with TET2 include Immunodeficiency 75 With Lymphoproliferation and …

2024年11月9日 · TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic …

2020年11月12日 · In various mammalian cells, Tet methylcytosine dioxygenase 2 (Tet2) catalyzes oxygen transfer to a methyl group of 5-methylcytosine (5mC), yielding 5 …

TET2 mutations are more widely reported and better understood in the context of myeloid disease than in solid tumors. Of the TET2 mutations (only accounting for frameshift, nonsense, and …

2023年8月11日 · Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

2009年5月28日 · We analyzed the consequences of deletions or mutations in TET2 with the use of in vitro clonal assays and transplantation of human tumor cells into mice.

2025年2月8日 · TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway. Nuclear localization of TET2 requires beta …

TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate- and Fe 2+ -dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has been …

2019年4月2日 · Here, we present a mini-review focused on the current understanding of TET2 in hematopoiesis, hematological malignancies, and immune regulation. Importantly, we highlight …