2024年12月25日 · TBK1 (TANK Binding Kinase 1) is a Protein Coding gene. Diseases associated with TBK1 include Encephalopathy, Acute, Infection-Induced 8 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Cytosolic sensors of pathogen-associated DNA.

2023年1月12日 · Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 enhances responses to PD-1...

2020年7月10日 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes.

2021年10月1日 · In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as therapeutic candidates. The inhibitor-kappaB kinase (IKK) family contains canonical and non-canonical IKK kinases.

TANK-binding kinase 1 (TBK1) is a serine/threonine kinase with well-established roles as a central player in innate immune signaling. Dysregulation of TBK1 activity has been implicated in a variety of pathophysiologic conditions, including cancer.

2025年2月9日 · TBK1-associated glaucoma exhibits classic features of NTG. Patients present with severe disease at a relatively early age and most (67%) have slow-to-moderate progression of their visual field defects. TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation in idiopathic pulmonary fibrosis.

2025年3月7日 · TBK1 (TANK binding kinase 1) and IKKε [inhibitor of nuclear factor κ B (NF- K B) kinase subunit ε] are two central kinases in the regulation of several cellular processes and immune pathways including autophagy, metabolism, …

2024年3月21日 · TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation.

2018年1月1日 · Also known as NAK (NF-κB-activating kinase) or T2K (TRAF2-associated kinase), TBK1 is a ubiquitously expressed 729-amino-acid serine/threonine kinase that is a noncanonical IκB kinase family member, targeting the transcription factors IRF3 and IRF7 in the type I interferon response.

2018年3月5日 · TBK1 phosphorylates AKT and promotes ubiquitin-dependent AKT degradation in T cells, thereby regulating T cell homeostasis and migration.