南京大学团队首次阐明了治疗哮喘和COPD的新靶点——苦味受体的作用机制 苦味受体（Tas2R）为G蛋白偶联受体（GPCR），除了感受味觉外，苦味受体还可以有效地…

2019年12月2日 · Humans possess approximately 25 bitter receptors (TAS2R) 12. Traditionally, it has been assumed that they initiate bitter taste perception in the oral cavity which serves as a central warning ...

研究团队主要成员（左至右：刘志杰教授、研究生胥维秀、华甜教授）（图片来源：上海科技大学iHuman研究所；摄影：周学迅） 科学家在这项工作中聚焦于 苦味受体TAS2R46。 这是一个广谱类苦味感知受体，可以识别多种不同结构类型的苦味分子，包括马钱子碱、奎宁、夏至草素等。其中，马钱子碱 ...

2023年6月7日 · To evaluate the agonistic efficacy of bile acids for human TAS2Rs, we compared the signal amplitudes of well-known TAS2R agonists with bile acids activating TAS2R1, TAS2R4, TAS2R14, TAS2R39 and...

2024年5月22日 · A cryogenic electron microcopy study of structures of a human receptor for bitter taste finds that cholesterol can activate the receptor, while the tastant molecule acts allosterically on the ...

2021年10月21日 · Overview of the canonical TAS2R signalling pathway. Upon TAS2R activation, the G-protein gustducin dissociates and activates phopholipase Cβ2 (PLCβ2), which subsequently leads to elevation in Ca 2+ from inositol-1,4,5 …

2022年2月1日 · In conclusion, TAS2Rs in the intestine constitute a promising target for treating diseases that involve disturbances in the innate immune system and body weight control. TAS2R polymorphisms may be valuable genetic markers to predict therapeutic responses. Keywords: G protein–coupled receptors; Gastroenterology; Innate immunity; Metabolism ...

2024年5月23日 · 5月22日，上海科技大学iHuman研究所、生命科学与技术学院华甜和刘志杰团队，联合山东大学基础医学院孙金鹏团队及上海交通大学医学院第九人民医院杨驰团队在《自然》（Nature）上以“文章加速预览 (Accelerated Article Preview, AAP)”形式在线发表了题为“Bitter taste TAS2R14 activation by intracellular tastants and ...

Humans perceive thousands of compounds as bitter. In sharp contrast, only approximately 25 taste 2 receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how the vast array of bitter compounds can be detected by such a limited number of sensors.

Scope: To avoid ingestion of potentially harmful substances, humans are equipped with about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit considerable variance in their bitter tasting abilities, which are associated with genetic polymorphisms in bitter taste receptor genes.