In molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells.

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel.

SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel.

In this review, we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function. Key Words: brain edema, epilepsy, Parkinson's disease, stroke, sulfonylurea receptor 1, SUR1, traumatic brain injury, TRPM4.

Sulfonylurea receptor 1 (Sur1) is among the most thoroughly studied proteins involved in ion channel formation (6–9). Sur1 is a member of the large superfamily of ATP-binding cassette proteins, most of which hydrolyze ATP to transport solutes across biological membranes.

2013年2月1日 · The sulfonylurea receptor 1 (Sur1)-NC(Ca-ATP) channel plays a central role in necrotic cell death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain and spinal cord injury.

Recent data, however, demonstrated the presence of SUR1 subunits in mouse cardiac tissue (particularly in atria) and a surprising protection from myocardial ischemia/reperfusion in SUR1-null mice.

Sulfonylurea Receptor 1 (SUR1) is a component of ATP-sensitive potassium channels in the pancreas and is also associated with a nonselective cation channel, TRPM4. It plays a crucial role in neurovascular unit response to mechanical trauma by regulating sodium influx, cell swelling, and cell death, particularly in traumatic brain injury scenarios.

The SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140-177 kDa expressed in the pancreas, brain, heart, and other tissues. It is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K ATP channels and …

2021年11月2日 · Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel.