Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple …

2012年5月1日 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small …

2023年10月16日 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody …

• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being …

2024年12月25日 · STEAP1 (STEAP Family Member 1) is a Protein Coding gene. Diseases associated with STEAP1 include Menkes Disease and Ewing Sarcoma . Among its related …

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)–targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer …

2024年7月3日 · AMG 509 is a humanized T-cell engager (TCE) molecule targeting STEAP1, which has shown promising results in phase I trials for metastatic castration-resistant prostate …

2025年1月6日 · ADRX-0405 is a next-generation antibody-drug conjugate (ADC) composed of a humanized IgG1 antibody targeting six-transmembrane epithelial antigen of the prostate 1 …

STEAP1 is an antigen that promotes cancer growth and spread and is found to be broadly expressed in mCRPC tissues. STEAP1 CART is composed of CAR T cells that have been …

3 天之前 · STEAP1-targeted therapy includes an antibody–drug conjugate (ADC), chimeric antigen receptor T cell (CAR-T), T-cell engager (TCE), and vaccines, which demonstrate …