Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. [5] [6] Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P). SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate (PA), a product of phospholipase D (PLD). [7]

2024年12月25日 · SPHK1 (Sphingosine Kinase 1) is a Protein Coding gene. Diseases associated with SPHK1 include Renal Fibrosis and Glioblastoma. Among its related pathways are Chaperonin-mediated protein folding and Antiviral mechanism by IFN-stimulated genes.

Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are lipid second messengers involved in diverse cellular processes.

Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting sphingosine to the signaling mediator sphingosine 1-phosphate (S1P). SPHK1 is widely overexpressed in most cancers, promoting tumor progression and is associated ...

2022年9月1日 · We have elucidated an emerging functionality of SPHK1, identified SPHK1-mediated immunosuppression established by transcriptional regulation of PD-L1 in malignant melanoma and demonstrated a...

2024年2月28日 · Our team overviewed SphK1 expression among different cancers, several resistance processes, S1P metabolism, S1P transport, S1P signaling, and SphKs inhibitors, with molecular docking for up-to-date all publicly available SphK1 inhibitors.

2024年12月10日 · Title: SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2.

2024年12月23日 · Pharmacological inhibition of Sphk1 with PF543 attenuates BBB leakage, reduces hematoma volume, and improves neurological outcomes in mice. At the molecular and ultrastructural level, Sphk1...

Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression. SPHK1 is involved in tumor development and progression of cervical cancer

2016年7月27日 · Sphingosine kinases (SPHKs) are the enzymes that catalyze the conversion of sphingosine to S1P. There are two isoforms, SPHK1 and SPHK2, which are encoded by different genes. SPHK1 has recently...