2024年12月25日 · SPAM1 (Sperm Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with SPAM1 include Mucopolysaccharidosis, Type Ix and Bladder Cancer. Among its related pathways are Fertilization and Meiosis. Gene Ontology (GO) annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is HYAL4.

Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1.

HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction.

透明质酸酶家族的六个成员在染色体 3p21.3 和 7q31.3 上聚集成两个紧密相连的组。 该基因以前被称为 HYAL1 和 HYA1，并被指定为官方符号 SPAM1；染色体 3p21.3 上的另一个家族成员被指定为 HYAL1。 该基因编码位于人类精子表面和顶体内膜上的 GPI 锚定酶。

2006年5月16日 · While SPAM1 transcripts are abundantly expressed only in the testis, specifically in spermatids, the RNA and protein are present in the male reproductive tract and accessory organs and in the female tract of mice. Our investigation of the post-testicular expression of SPAM1 shows that the protein is widely expressed in the epididymis.

2003年8月6日 · The Sperm Adhesion Molecule 1 (SPAM1) is an important sperm surface hyaluronidase with at least three functions in mammalian fertilization. Previously our laboratory reported that in the mouse, in addition to its expression in the testis, Spam1 is synthesized in the epididymis where it is found in membranous vesicles in the principal cells of ...

2025年2月8日 · SPAM1 may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix. First documentation of vesicular interaction with the sperm plasma membrane provides a model for the possible transfer mechanism of SPAM1 and other glycosyl phosphatidylinositol (GPI)-linked proteins to the sperm surface in reproductive fluids.

SPAM1 (sperm adhesion molecule 1) is a hyaluronidase implicated in the dispersion of the cumulus-oocyte matrix. Therefore, the aim of this study was to characterize the SPAM1 distribution in the different physiological conditions of human sperm.

2006年5月16日 · The most widely conserved mammalian sperm antigen is sperm adhesion molecule 1, SPAM1/PH-20, which is also the major testicular hyaluronidase. This multifunctional glycosyl phosphatidylinositol (GPI)-linked protein plays several roles in fertilization and is encoded by a gene that resides among hyal …

透明质酸酶家族的六个成员都聚集成两个紧密联系组3p21.3区上染色体7q31.3。 该基因以前被称为HYAL1和HYA1，至今已分配的官方标志SPAM1;染色体3p21.3的其他家庭成员已分配HYAL1。 该基因编码位于人类精子表面和顶体内膜上GPI锚定酶。