Snf1 protein kinase: a key player in the response to cellular
Sucrose non-fermenting 1 (Snf1) protein kinase, a yeast homologue of mammalian AMP-activated protein kinase, plays a main role in transcriptional activation and repression of gene …
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
2014年5月19日 · The SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein …
Conventional and emerging roles of the energy sensor Snf1…
Snf1 shares evolutionary conserved functions with the AMP-activated Kinase (AMPK) in higher eukaryotes which, activated by energy depletion, stimulates catabolic processes and, at the …
SNF1-related protein kinase 1: the many-faced signaling hub
2021年9月2日 · The Snf1-related protein kinase 1 (SnRK1) is the plant homolog of the heterotrimeric AMP-activated protein kinase/sucrose non-fermenting 1 (AMPK/Snf1), which …
AMP-activated/SNF1 protein kinases: conserved guardians of …
2007年10月1日 · Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was …
SNF1/AMPK/SnRK1 kinases, global regulators at the heart of
The SNF1-related kinases are considered to be crucial elements of transcriptional, metabolic and developmental regulation in response to stress. In yeast, SNF1 is one of the main regulators in …
SNF1/AMPK pathways in yeast - PMC - PubMed Central (PMC)
SNF1 regulates transcription of a large set of genes, modifies the activity of metabolic enzymes, and controls various nutrient-responsive cellular developmental processes. Like AMPK, SNF1 …
Network reconstruction and validation of the Snf1/AMPK pathway ... - Nature
2015年10月22日 · The yeast SNF1 complex is best known for its role in glucose derepression. We performed a network reconstruction of the Snf1 pathway based on a comprehensive …
SUMOylation regulates the SNF1 protein kinase - PMC
2013年10月10日 · We show that Snf1, the catalytic subunit of AMPK of the yeast Saccharomyces cerevisiae, is modified by attachment of the small ubiquitin-like modifier SUMO, which inhibits …
The Yeast AMPK Homolog SNF1 Regulates Acetyl Coenzyme A …
Here we show that SNF1, the budding yeast ortholog of the mammalian AMP-activated protein kinase (AMPK), plays a role in the regulation of acetyl-CoA homeostasis and global histone …
Regulatory Functions of Cellular Energy Sensor SNF1-Related
2017年6月9日 · Our plant cell-based functional and biochemical assays have demonstrated that SNF1-RELATED KINASE1 (SnRK1) directly interacts, phosphorylates, and destabilizes the …
AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein
In yeast, SNF1 protein kinase is the orthologue of mammalian AMPK complex. It is a trimeric complex composed of Snf1 protein kinase (orthologue of AMPKα catalytic subunit), Snf4 …
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
The SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein kinase). These …
The role of the SNF1 signaling pathway in the growth of
Herein, we provide evidence that the SNF1 gene is necessary to maintain S. cerevisiae growth with glucose as a sole carbon source at every concentration tested. Resveratrol …
Regulation of Snf1 Kinase - Journal of Biological Chemistry
Our data indicate that activation of the Snf1 kinase complex involves two steps, one that requires a distinct upstream kinase and one that is mediated by the γ subunit of the kinase itself.
The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: …
2011年8月25日 · The AMP-activated kinase (AMPK)/sucrose nonfermenting1 (SNF1)/Snf1-related kinase1 (SnRK1) protein kinases are evolutionarily conserved metabolic sensors found …
β‐subunits of Snf1 kinase are required for kinase function and ...
2000年9月15日 · The Snf1 kinase and its mammalian homolog, the AMP‐activated protein kinase, are heterotrimeric enzymes composed of a catalytic α‐subunit, a regulatory γ‐subunit and a …
Subcellular localization of the Snf1 kinase is regulated by specific …
Snf1 kinase complexes contain the α (catalytic) subunit Snf1, one of the three related β subunits Gal83, Sip1, or Sip2, and the γ subunit Snf4. We present evidence that the β subunits regulate …
Localization and phosphorylation in the Snf1 network is
2021年6月14日 · We show that the Snf1 pathway reacts both to the presence and to the absolute concentration of glucose. Furthermore, we identify a negative feedback loop regulating Snf1 …
Exploring carbon source related localization and phosphorylation …
We show that Snf1 responds to glucose with a decreased recovery rate during FRAP already at low glucose concentrations and that nuanced phosphorylation of Snf1 in response to various …
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