2024年12月25日 · SKP1 (S-Phase Kinase Associated Protein 1) is a Protein Coding gene. Diseases associated with SKP1 include Mitochondrial Dna Depletion Syndrome 13 and Parkinson Disease 15, Autosomal Recessive Early-Onset. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Toll Like Receptor 7/8 (TLR7/8) …

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six …

Skp1 (S-phase kinase-associated protein 1) is a core component of the SCF (Skp1-Cullin 1-F-box) E3 ubiquitin ligase complex necessary for protein degradation by the 26S proteasomal pathway. The rice blast fungus Magnaporthe oryzae has a single MoSKP1 (MGG_04978) required for viability.

The SKP1‐CUL1‐F‐box (SCF) E3 ubiquitin ligase, a member of the Cullin‐RING E3 ubiquitin ligase (CRL) family, plays a crucial role in mediating protein ubiquitination and subsequent 26S proteasome degradation during normal cellular metabolism.

2023年10月13日 · We found that, under nutrient-poor conditions, SKP1 is phosphorylated on Thr 131, allowing its interaction with V 1 subunits of the vacuolar ATPase (V-ATPase). This event, in turn, promotes V-ATPase assembly to acidify late endosomes and …

Skp1 is an essential adaptor protein of the Skp1-Cul1-F-box protein complex and is able to stabilize the conformation of some ubiquitin E3 ligases. However, the role Skp1 plays during tumorigenesis remains unclear and Skp1-targeting agent is lacking.

2024年1月26日 · Clinical resource with information about SKP1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

S phase kinase-associated protein 1 (Skp1)-Cullin1-F-Box protein (SCF) complexes are the best characterized among CRLs, which play crucial roles in numerous cellular processes and physiological dysfunctions, such as in cancer biology.

2024年11月3日 · Title: The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.

2005年9月13日 · Bai et al. (1996) cloned SKP1 and determined that it binds to cyclin F (CCNF; 600227), SKP2, and potentially to other regulatory proteins that may be involved in ubiquitin proteolysis. Binding occurs through a novel motif, termed the F box.