2025年3月31日 · The SHANK2 gene, located on the 11th chromosome, provides the code for producing SHANK2 protein which is essential for proper brain function. SHANK2 protein plays an integral role in the transmission of messages from one neuron to the next.

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. [5] [6] Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [6]

WHAT IS THE SHANK2 GENE? The SHANK2 gene, located on the 11th chromosome in location 13 (11q13), provides the genetic code to produce SHANK2 protein. This protein is essential for proper brain function because it helps transmit messages from one brain cell (neuron) to another.

2024年12月25日 · SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2) is a Protein Coding gene. Diseases associated with SHANK2 include Autism 17 and Rare Disease With Autism. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses.

Interestingly, a mammalian homolog of Prosap, SHANK2, is the most frequently amplified gene on 11q13, a major tumor amplicon in human cancer. Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.

2012年2月7日 · The fan-favorite 2D brawler is back as ex-mob hit man Shank returns to action in Shank 2. With those closest to him under attack, Shank is once again forced on the offensive.

2021年1月22日 · Cells with bi-allelic SHANK2 mutations revealed diminished apoptosis and increased proliferation, as well as decreased neurite outgrowth during early neuronal differentiation.