2017年4月28日 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that …

2023年5月11日 · Here we present near-atomic-resolution structures of human Sec61 inhibited by a comprehensive panel of structurally distinct small molecules—cotransin, decatransin, …

2017年11月1日 · Recently, cryoelectron tomography of translocons in native ER membrane vesicles, derived from human cell lines or patient fibroblasts, and even intact cells has given …

These structural data are discussed in light of different Sec61 channel activities including ribosome receptor function, membrane insertion, and translocation of newly synthesized …

The Sec61 complex appears to be a good candidate to explain the mechanism of Ca 2+-store depletion associated with ER stress and UPR. The role of the Sec61 complex in cell death and …

The Sec61 complex provides a high-affinity docking site for the ribosome–nascent chain complex. Additional factors thought to facilitate binding of the signal sequence to the Sec61 complex …

2023年1月3日 · The universally conserved protein-conducting channel Sec61 complex mediates core steps in these processes by translocating hydrophilic polypeptide segments of client …

2017年4月28日 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that …

2016年1月1日 · Here, we use electron cryo-microscopy to determine the structure of an active Sec61 channel that has been opened by a signal sequence. The signal supplants helix 2 of …

2017年10月31日 · Recently, cryoelectron tomography of translocons in native ER membrane vesicles, derived from human cell lines or patient fibroblasts, and even intact cells has given …