Keywords: scleroderma, antibodies, phenotype. Introduction. The presence of scleroderma-specific autoantibodies has long been recognized, as has their association with distinct clinical phenotypes and utility for assessing risk and long-term prognosis 1. New research continues to provide important insights into the utility of antibody ...

Keywords: anti-centromere, anti-Scl-70, autoantibodies, scleroderma, systemic sclerosis. Introduction. Systemic sclerosis (scleroderma or SSc) is a heterogeneous disorder characterized by autoantibody subsets, which in turn have their own clinical associations. Much controversy resides in whether these autoantibodies contribute directly to the ...

2024年11月1日 · Most people with scleroderma have autoantibodies. Several scleroderma-specific antibodies have been identified. These can help with diagnosis and give insight into the type of disease you may ...

Research shows that fewer than 2% of systemic scleroderma patients have more than one positive scleroderma specific antibody when testing problems are eliminated. Table 2: lists all generally accepted scleroderma-related antibodies along with some general information on risks and other clinical associations.

Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. ... Sobel ES, Reeves WH, Satoh M. Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies. Clin Rheumatol. 2011;15:1333–1339. doi: 10.1007/s10067-011-1751-0. [PMC free article] [Google ...

People with anticentromere antibodies tend to develop pulmonary arterial hypertension (PAH). There are six other scleroderma-related autoantibodies that are far less common. They may be seen in people who also have another, overlapping connective tissue disease, like polymyositis or dermatomyositis: Anti-fibrillarin (U3RNP) Anti-Th/To; Anti-U11 ...

2003年2月12日 · Scleroderma (systemic sclerosis) is associated with several autoantibodies, each of which is useful in the diagnosis of affected patients and in determining their prognosis. Anti-centromere antibodies (ACA) and anti-Scl-70 antibodies are very useful in distinguishing patients with systemic sclerosis (SSc) from healthy controls, from patients with other …

Purpose of review: New research continues to provide important insights into the utility of antibody specificities. This review provides an update of recent findings, and the important insights they provide into disease mechanism. Recent findings: A growing number of autoantibodies have been discovered in scleroderma patients with unique clinical associations.

2016年6月14日 · The importance of autoantibodies in systemic sclerosis (SSc) diagnosis and prognosis has been increasingly recognized. This review discusses the current knowledge of autoantibodies in systemic sclerosis (SSc) with respect to clinical care. We focus primarily on the SSc-associated serum autoantibodies and their recognized SSc clinical phenotypes or …

2020年11月18日 · Introduction. Systemic sclerosis (SSc) or scleroderma is a chronic multi-system disease with heterogeneous manifestations ().There is still a lack of recommendations with strong evidence regarding the diagnosis and management of several SSc-specific complications (), leading to a reduced quality of life and an enormous burden for patients.The mechanism …