Insulin modulates the SREBP pathway through transcriptional and post-transcriptional mechanisms that emerge from the mTOR pathway. Modulation of the SREBP pathway contributes to innate immunity and development of cancer. Acknowledgments

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a range of enzymes required for endogenous cholesterol, fatty acid (FA), triacylglycerol and phospholipid synthesis. The three SREBP isoforms, SR …

2017年8月29日 · SREBP directly induces expression of oncogenic IDH1 and increases production of 2-hydroxyglutarate, a key oncometabolic regulator produced from glucose, which demonstrates that SREBPs can...

The SREBPs play related but distinct roles: SREBP-1c, the predominant SREBP-1 isoform in adult liver, preferentially activates genes required for fatty acid synthesis, while SREBP-2 preferentially activates the LDL receptor gene and various genes required for …

Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis. Recent studies reveal expanding roles for SREBPs with the description of new regulatory mechanisms, identification of ...

2019年3月22日 · SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins.

Changes in cell metabolism and growth are reciprocally linked through SREBPs. Anabolic and growth signalling pathways branch off and connect to multiple steps of SREBP activation and form complex regulatory networks.

2013年1月1日 · The effects of mTORC1 on SREBP can be divided into three levels: (i) transcription level, mTORC1 can elevate SREBP-1c mRNA; (ii) proteolytic processing level, mTORC1 can enhance proteolytic processing through activating S6K; (iii) n-SREBP level, mTORC1 can repress Lipin-1 to increase n-SREBP abundance.

1997年5月2日 · In humans, hamsters, and mice, two members of the SREBP family, designated SREBP-1a and SREBP-1c, are produced from a single gene (human chromosomal location, 17p11.2) through the use of alternate transcription start sites encoding alternate first exons that are spliced into a common second exon (Yokoyama et al. 1993; Hua et al. 1995b ...

2001年11月1日 · SREBPs have unique characteristics. Firstly, they are membrane-bound proteins and the N-terminal active portions enter nucleus to activate their target genes after proteolytic cleavage, which requires sterol-sensing molecule, SREBP-activating protein (SCAP) and is crucial for sterol-regulation.