2024年12月25日 · SIRT5 (Sirtuin 5) is a Protein Coding gene. Diseases associated with SIRT5 include Urea Cycle Disorder and Hypertrophic Cardiomyopathy. Among its related pathways are NAD metabolism and Transcriptional activation of mitochondrial biogenesis.

2022年6月5日 · In this review, we summarize the current understanding of the structure and biological function of SIRT5, review the chemical structures and biological activity of SIRT5 inhibitors and offer insights for the future exploitation of SIRT5 inhibitors.

SIRT5 regulates protein substrates involved in glycolysis, TCA cycle, fatty acid oxidation, electron transport chain, ketone body formation, nitrogenous waste management, and ROS detoxification, among other processes.

Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant responses, and is an important regulator for maintaining intracellular homeostasis.

SIRT5, which localizes to the mitochondrial matrix and is ubiquitously expressed, functions as a weak NAD +-dependent deacetylase. SIRT5 null mice have been generated and are developmentally normal without obvious metabolic defects (Lombard et …

2023年11月25日 · In this study, we demonstrate that ME2 is highly expressed in human colorectal cancer (CRC) tissues, and that ME2 knockdown inhibits the proliferation of CRC cells. Furthermore, we reveal that ME2...

SIRT5 regulates protein substrates involved in glycolysis, the TCA cycle, fatty acid oxidation, electron transport chain, ketone body formation, nitrogenous waste management, and ROS detoxification, among other processes.

2025年2月8日 · SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes. Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability. SIRT5 is a proviral factor …

6 天之前 · SIRT5 is a desuccinylase that functions by catalyzing the removal of succinylation, thereby inhibiting protein succinylation. Evidence has revealed the potential roles of SIRT5 in various human heart diseases. Importantly, SIRT5’s impact on I/R-induced myocardial injury has been previously documented . However, whether SIRT5 affects apoptosis ...

2022年6月5日 · SIRT5 is thought to be closely related to some diseases such as cancer and neurodegenerative diseases. Herein, we present an overview of the structure and biological function of SIRT5 as well as the advances in SIRT5 inhibitors research.