2025年1月8日 · Through metabolomic identification and subsequent investigation, they finally found the molecular analogue of CR, lithocholic acid, and verified the effect of LCA on …

Lv QK, Tao KX, Yao XY, Pang MZ, Cao BE, Liu CF, Wang F.Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's …

2013年9月11日 · That suggests that Sirt1 specifically in the dorsomedial and lateral hypothalamus is important for the anti-aging effect. Imai speculates that this could help settle the controversy …

Improvement Effect of Mitotherapy on the Cognitive Ability of Alzheimer's Disease through NAD+/SIRT1-Mediated Autophagy. Antioxidants (Basel). 2023 Nov 16;12(11) PubMed. …

2021年4月30日 · BPN14770 antagonized the amnestic effect of the anti-nausea drug scopolamine, whereby two weeks’ dosing boosted hippocampal phospho-CREB and BDNF, …

2024年12月19日 · They showed that SIRT1 competes with SIRT2, preventing APP from being deacetylated, hence decreasing the production of Aβ (Li et al., 2023). Another study reported …

Wang Y, Gao S, Zheng V, Chen L, Ma M, Shen S, Qu J, Zhang H, Gurney ME, O'Donnell JM, Xu Y.A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via …

2008年2月22日 · That puts Sirt1 squarely in the driver’s seat of mitochondrial turnover, since the sirtuins also govern the generation of new mitochondria. The latter action of Sirt1 depends on …

2010年7月16日 · In the SIRT1 KOs, higher expression of miRNA-134 inhibits CREB production, and ultimately leads to less BDNF in the brain. To nail down this mechanism, the authors …

2008年11月21日 · These data suggest that loss of SIRT1 occurs at relatively late stages of AD, Calon told ARF. The full paper is currently in press in the Journal of Neuropathology and …