2024年12月25日 · SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1) is a Protein Coding gene. Diseases associated with SETDB1 include Huntington Disease and Hyperoxaluria, Primary, Type I. Among its related pathways are Regulation of endogenous retroelements and PKMTs methylate histone lysines.

SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. In B lymphocytes, SETDB1 mediates the transition from pro-B to pre-B cells and represses endogenous retroviruses (ERV) to …

2021年5月5日 · SETDB1 loss derepresses latent TE-derived regulatory elements, immunostimulatory genes, and TE-encoded retroviral antigens in these regions, and triggers TE-specific cytotoxic T cell...

2021年8月11日 · The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3-9 (SUV39)-related protein lysine methyltransferases (PKMTs), comprising three isoforms that …

2020年4月22日 · SET domain, bifurcate 1 (SETDB1), functioning as a histone H3K9 specific methyltransferase, is not only critically involved in transcriptional silencing and local heterochromatin formation,...

SETDB1 has five main functions: 1) Epigenetic Effects: SETDB1 is an epigenetic modifier involved mainly in H3K9 methylation. It can also contribute to H3K27 and DNA methylation. 2) PML-NB Formation: SETDB1 is an integral component of PML-NB structures which are essential for multiple functions.

SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 (H3K9) methyltransferase that exerts important effects on epigenetic gene regulation. SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in ...

2017年7月3日 · We show that the SETDB1 repressor complex, which involves multiple KRAB zinc finger proteins, shields neuronal genomes from excess CTCF binding and is critically required for structural...

SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of …

2025年1月24日 · Our findings show that SetDB1 auto-methylation is essential for the spreading and stable maintenance of heterochromatin. This includes its roles in processes such as X-chromosome inactivation and the negative feedback regulation of a large gene family encoding KRAB-ZNF transcriptional repressors.