SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in …

2024年12月25日 · Complete information for SAMHD1 gene (Protein Coding), SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1, including: function, …

SAMHD1 is a dNTPase Comprised of an N-terminal SAM Domain, a Central HD Domain, and C-Terminal Regulatory Domain.

2018年4月18日 · Here we show that SAMHD1 promotes degradation of nascent DNA at stalled replication forks in human cell lines by stimulating the exonuclease activity of MRE11. This …

2020年3月31日 · SAMHD1 plays a variety of roles in virology, immunology, and cell biology. The dNTPase activity of SAMHD1 depletes intercellular dNTP pools in macrophages, restricting …

2014年2月13日 · SAMHD1 degrades dNTPs into deoxynucleosides (dN) and inorganic triphosphates (PPP). Low levels of dNTPs decrease DNA synthesis, slow down cell cycle …

SAMHD1 is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is …

The SAMHD1 gene provides instructions for making an enzyme that helps cut molecules called deoxynucleoside triphosphates (dNTPs). Learn about this gene and related health conditions.

2025年1月4日 · Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels. Guanine …

2022年9月22日 · Our results establish SAMHD1 as a key regulator of cellular RNA homeostasis and demonstrate that buffering of immunogenic self RNA by condensates regulates innate …