The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (K ir 1.1) that transports potassium out of cells. It plays an important role in potassium …

Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at …

The apically located renal outer medullary K + (ROMK) channel provides a pathway for K + to recycle from cell to lumen, and ensures an adequate supply of K + to sustain Na +-K +-2Cl − …

2009年10月1日 · ROMK encodes a major potassium secretory channel in the kidney. In distal nephron principal cells, ROMK1 and ROMK3 form the predominant 30-pS potassium channel. …

The renal outer-medullary K+ channel (ROMK; Kir1.1) mediates K+ secretion in the renal mammalian nephron that is critical to both sodium and potassium homeostasis. The …

A large body of evidence indicates that ROMK channel activity is regulated by endocytosis and exocytosis. ROMK channels have been shown to interact with clathrin via AP-2 protein .

In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an …

2009年3月30日 · Here we provide a compre-hensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the …

ROMK (Kir1.1) is a potassium channel that is primarily found on the apical surface of epithelial cells in the thick ascending limb of Henle (TALH) and cortical collecting duct (CCD) in the …

ROMK, or the Renal Outer Medullary Potassium channel, is a critical component in the regulation of potassium homeostasis within the kidney. It is responsible for the reabsorption and …