2024年12月25日 · RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Raynaud Disease and Retinitis Pigmentosa 3. Among its related pathways are Transport of the SLBP independent Mature mRNA and HIV Life Cycle.

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein. [5] RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase. RCC1 has been shown to interact with RANBP3 [6][7] and Ran (biology). [8][9][10][11] ^ "Human PubMed Reference:".

2008年8月1日 · The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51–68 amino acid residues, which were later shown to adopt a seven-bladed β-propeller fold.

RCC1 regulates KT composition at the metaphase-anaphase transition in a Ran-GTP independent fashion through displacement of Shugoshin-1 and chromosomal passenger complex. This study provides first evidence for a mutation in RCC1 as a breast cancer susceptibility allele

2022年2月28日 · RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog). RCC1 plays an essential role in the regulation of cell cycle-related activities such as nuclear envelope formation, nucl …

2010年8月25日 · Here we determine the crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 Å resolution, providing an atomic view of how a chromatin protein interacts with...

RCC1 is the GDP–GTP exchange factor for the small GTPase Ran, which is involved in several essential cellular processes, including nucleocytoplasmic transport, nuclear envelope assembly and mitotic spindle formation. RCC1 was first discovered as a ṟegulator of c̱hromosome c̱ondensation and has long been known to bind to chromatin.

RCC1 Antibody recognizes endogenous levels of total RCC1 protein. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues in the central region of human RCC1.

Renal cell carcinoma (RCC) is a heterogeneous group of cancers arising from renal tubular epithelial cells that encompasses 85% of all primary renal neoplasms 1, 2. The most common subtypes of RCC are clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC 1. The remaining 15% of tumors of the kidney consist of transitional cell carcinoma (8 ...

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