Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser536 of human NF-κB p65. Transcription factors of …

HCMV pp65 dampens IFN-β production by inactivating the cGAS/STING/IRF3 axis. HCMV infection can be detected by multiple innate sensing pathways, including TLR2 and TLR9, in …

2007年12月6日 · Here, we show that proteins fused to the human cytomegalovirus tegument protein pp65 were bound with higher efficiency to DCs than those fused to the described PTDs …

To comprehensively analyze CD8 + T cell responses against the CMV pp65 antigen restricted by a single HLA class I allotype, we conducted ELISPOT assays using an artificial antigen …

2012年1月17日 · Pp65 is the most abundant tegument protein and the major constituent of extracellular virus particles . However, pp65 is not essential for the production of new …

Here we describe a pp65‐derived peptide (pp65 340–355, RQYDPVAALFFFDIDL: RQY16‐mer), characterized by peculiar features. First, RQY‐16mer is able to stimulate HCMV pp65 specific …

2020年6月15日 · Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes. J Med Virol 43, 103–110 (1994).

2025年1月13日 · The understanding of pp65’s interactions and functions provides a foundation for vaccine design against HCMV. A promising strategy involves developing vaccines that can …

CMV pp65 – Recombinant Protein is specially developed for efficient in vitro stimulation of pp65-specific CD4 + and CD8 + T cells, for example, causing secretion of effector cytokines.

The most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosphoprotein 65 (pp65), which is frequently included in CMV vaccines. …