PGAM family member 5 (PGAM5), also known as mitochondrial Serine/threonine-protein phosphatase PGAM5 is related to phosphoglycerate mutase family. It, in humans, is encoded by the PGAM5 gene on chromosome 12.

2024年12月25日 · Complete information for PGAM5 gene (Protein Coding), PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase, including: function, proteins, disorders, pathways, orthologs, and expression.

2025年2月21日 · PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis, and pyroptosis.

2021年1月1日 · PGAM5 activates mitochondrial biogenesis and mitophagy to promote a cellular compensatory response when mitochondria are mildly damaged, whereas severe damage to mitochondria leads to PGAM5 inducing excessive mitochondria fission, disruption to mitochondrial movement, and amplification of apoptosis, necroptosis and mitophagic death signals, whic...

2020年5月21日 · Phosphoglycerate mutase 5 (PGAM5) is a mitochondrial Serine (Ser)/Threonine (Thr) phosphatase normally located in the inner mitochondrial membrane. Upon mitochondrial dysfunction, PGAM5...

PGAM5 activates mitochondrial biogenesis and mitophagy to promote a cellular compensatory response when mitochondria are mildly damaged, whereas severe damage to mitochondria leads to PGAM5 inducing excessive mitochondria fission, disruption to mitochondrial movement, and amplification of apoptosis, necroptosis and mitophagic death signals ...

PGAM5 interacts with MFN2 in a stress-sensitive manner. The PGAM5-MFN2 interaction protects MFN2 from phosphorylation and enhances its stability and fusogenic activity. PGAM5 depletion results in enhanced MFN2 phosphorylation, suggesting its role as a possible MFN2 phosphatase.

2025年2月10日 · Here we review the structure and sublocalization of PGAM5, introduce its importance in programmed cell death and summarize its crucial roles in the development and progression of inflammatory...

2019年1月31日 · Phosphoglycerate mutase family member 5 (PGAM5) is an atypical protein phosphatase implicated in a number of functions within mitochondria, including organelle homeostasis, mitophagy, and...

2025年2月9日 · PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction.