2009年7月1日 · PfEMP1 was shown to be a key molecule in defining the cytoadhesive properties of the iRBC to neighboring uninfected RBCs, forming structures called rosettes, as well as binding to several endothelial receptors.

2023年5月8日 · During the evolutionary arms race between the Plasmodium parasite and humankind, P. falciparum has evolved strategies to antagonize the function of IgM. Plasmodium falciparum erythrocyte...

2001年11月15日 · The malarial protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a parasite protein that is exported to the surface of the infected erythrocyte, where it is inserted into the red cell cytoskeleton in the second half of the parasite life cycle.

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte membrane and mediate binding of infected erythrocytes to the endothelial lining of blood vessels.

2015年4月1日 · PfEMP1 plays an important role in P. falciparum rosetting, which is a diverse adhesion phenotype that appears to involve multiple PfEMP1 ligands and several erythrocyte receptors (reviewed by Mercereau-Puijalon et al., 2008).

In this review, we will focus on the role of the P. falciparum membrane protein 1 (PfEMP1) family of VSA as targets of naturally acquired immunity and review their potential as vaccine targets. There have been extremely encouraging developments in this …

Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent.

We investigated the immunosuppressive effect of PfEMP1 on monocytes/macrophages, which are central to the antiparasitic innate response. RAW macrophages and human primary monocytes were stimulated with wild-type 3D7 or CS2 parasites or transgenic PfEMP1-null parasites.

We are studying the role of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed by asexual stages of P. falciparum responsible for the pathogenicity of severe malaria. The immunopathology of falciparum malaria has been linked to cyto-adhesion of infected erythrocytes to specific host receptors.

As the antibody response against the single expressed PfEMP1 develops, small sub-populations of parasites switch expression to alternative forms of PfEMP1 and re-establish the infection. Therefore, PfEMP1 is considered a key player in the pathogenicity of P. falciparum.