PARP7 negatively regulates the type I interferon response in …
2021年9月13日 · PARP7 is a therapeutic target whose inhibition induces both cancer cell-autonomous and immune stimulatory effects via enhanced IFN signaling. These data support …
PARP7 inhibits type I interferon signaling to prevent …
PARP7 is the most potent negative feedback regulator of IFN-I production. Using Parp7−/− and Parp7H532A/H532A mice, we show that PARP7 loss leads to systemic autoimmunity …
PARP7 and nucleic acid-driven oncosuppression
2024年6月4日 · TCDD-inducible poly (ADP-ribose) polymerase (TIPARP, best known as PARP7) has previously been shown to promote oncogenesis by limiting the cytosolic accumulation of …
Discovery of the Potent and Highly Selective PARP7 Inhibitor as a …
2022年12月28日 · PARP7, a polyadenosine diphosphate-ribose polymerase, has been identified as a negative regulator in type I interferon (IFN) signaling. An overexpression of PARP7 is …
Identification of PARP-7 substrates reveals a role for MARylation …
To identify the MARylated substrates of PARP-7 in ovarian cancer cells, we developed an NAD + analog-sensitive approach, which we coupled with mass spectrometry to identify the PARP-7 …
PARP7 is a ther-apeutic target whose inhibition induces both cancer cell-autonomous and immune stimulatory effects via enhanced IFN signaling. These data support the targeting of a …
Identification of PARP-7 substrates reveals a role for ... - PubMed
2021年1月21日 · To identify the MARylated substrates of PARP-7 in ovarian cancer cells, we developed an NAD + analog-sensitive approach, which we coupled with mass spectrometry to …
Novel PARP7 Inhibitors for Treating Cancer - ACS Publications
2025年3月20日 · PARP7 inhibitors have been shown to restore type I interferon (IFN) signaling responses to nucleic acids and causes tumor regression in a CT26 tumor-bearing, …
PARP7 Inhibition: A Promising Pathway to Advancements in …
2023年8月8日 · While no approved PARP7 inhibiting pharmaceuticals currently exist, this Patent Highlights showcase compounds and formulations with potential as potent PARP7 inhibitors, …
PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen …
PARP7 (TIPARP; ARTD14) is a mono-ADP-ribosyltransferase involved in several cellular processes, including responses to hypoxia, innate immunity and regulation of nuclear …