PAK2 signaling modulates apoptosis, [10] endothelial lumen formation, [11] viral pathogenesis, [12] and cancer including, breast, [13] hepatocarcinoma, [14] gastric [15] and cancer, at-large, [16] and, based on its kinase activity alone, peripheral …

2024年12月25日 · PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Knobloch Syndrome 2 and Knobloch Syndrome. Among its related pathways are Signaling by Rho GTPases and Autodegradation of the E3 ubiquitin ligase COP1.

2025年2月1日 · PAK2 plays a key role in regulating T cell maturation and differentiation. Studies show that the absence or dysfunction of PAK2 disrupts the production of essential receptor proteins during T cell maturation, resulting in impaired T cell function and enabling tumor cells to evade immune surveillance (Fig. 3 B) [49]. Specifically, PAK2 ...

This review provides a comprehensive overview of PAK2's role in cancer, focusing on its involvement in processes such as angiogenesis, metastasis, cell survival, metabolism, immune response, and drug resistance.

In this review, we discuss the mechanisms of Pak activation in cancer, the key substrates for this family of kinases that mediate their developmental and oncogenic effects, and how small molecule inhibitors of these enzymes might best be developed and deployed in the treatment of cancer.

2023年2月22日 · We demonstrated that PAK2’s interaction with PLK1 protected it from degradation by APC/C Cdh1, and that it promoted meiotic progression and bipolar spindle formation. Our data collectively...

2021年10月25日 · PAK2 facilitates STAT5 translocation in CML as well, and drives the Rac-PAK-Cofilin pathway, leading to increased ROS production.

2024年12月15日 · PAK2 is a serine-threonine kinase and a member of the p21-activated kinase (PAK) family. PAK2 is activated by GTP-bound rho family GTPases, Rac, and Cdc42, and it regulates actin dynamics, cell adhesion to the extracellular matrix, and cell motility.

Our findings uncover a new cardioprotective mechanism, which promotes a protective ER stress response via the modulation of Pak2. This novel therapeutic strategy may present as a promising option for treating cardiac disease and heart failure.

2019年6月3日 · Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Interestingly, PAK2 activation and its control of the apoptotic response are specific for the amplitude of force applied.