PRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations.

2024年12月25日 · PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Myeloma, Multiple and Plasmablastic Lymphoma. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

PRDM1 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

The Prdm1-iCre (Blimp1-iCre) mouse is generated by integrating the P2A-iCre expression cassette into the stop codon of the mouse Prdm1 gene. Under the control of mouse Prdm1 gene regulatory elements, this strain expresses iCre recombinase (codon-optimized Cre recombinase).

2020年12月15日 · Background: PR domain zinc finger protein 1 (PRDM1) is a regulator of both B cell and T cell differentiation and plays a critical role in immunosuppression. Its role in tumor immunity and correlation with drug response remain unknown.

2024年11月5日 · Using CRISPR/Cas9 targeting, we have demonstrated that PRDM1 -deficient CAR T cells exhibit enhanced proliferative capacity, memory characteristics, and resilience against exhaustion upon repeated stimulation.

2023年11月2日 · In NK-cells, deletion of PRDM1 has been shown to promote cell growth and survival in vitro, and its loss of function was commonly detected in NK-cell lymphomas. Here, we employed a multi-omics approach to investigate the role of PRDM1 in the differentiation of human primary NK-cells.

2019年11月13日 · PRDM1 bound a large number of genes in the NK or T cell receptor signaling pathway, which are employed during NK cell activation. In addition, several genes encoding immune checkpoints that may restrict NK cell activation such as TIGIT, HAVCR2 (TIM3), and IL-1R8 were targeted by PRDM1.

2024年1月18日 · Prdm1 facilitates the intercellular communication between liver group 1 ILCs and macrophages. The reciprocal crosstalk between group 1 ILCs and macrophages plays a critical role in maintaining liver immune homeostasis and anti-cancer immune surveillance (53, 54).

Using Ncr1-drived conditional knockout mouse model, our study reveals the regulatory role of Prdm1 in shaping the composition and maturation of liver Type 1 ILCs. Notably, Prdm1 regulates the ratio between NK cells and ILC1s, promoting a shift in …