2024年12月25日 · POU5F1 (POU Class 5 Homeobox 1) is a Protein Coding gene. Diseases associated with POU5F1 include Embryonal Carcinoma and Teratoma . Among its related pathways are Gastrulation and Meiosis .

POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6. A paradigm for post-embryonic Oct4 re-expression: E7-induced hydroxymethylation regulates Oct4 expression in cervical cancer.

2013年4月3日 · We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent...

2023年12月7日 · POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. The impact of POU5F1 on the proliferation and metastasis of GC was...

POU5F1 as a pan‐cancer gene could be a prognostic and diagnostic biomarker in various cancers, especially in LIHC. Elevated POU5F1 might promote the transformation of B cells naive into B cells memory in LIHC. POU5F1 may play a vital role in LIHC through CBX3, CCHCR1, and NFYC to regulate some cancer‐related pathways. 1. INTRODUCTION

POU5F1 is a transcription factor essential for the self-renewal activity and pluripotency of embryonic stem cells and germ cells. We have previously reported that POU5F1 is fused to EWSR1 in a case of undifferentiated sarcoma with chromosomal translocation t (6;22) (p21;q12).

2025年2月18日 · Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past the pluripotency stage. Compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos.

The translocation resulted in a POU5F1/EWS (EWSR1; 133450) chimeric gene composed of the N-terminal domain of EWS that functions as a transcriptional activation domain and the C-terminal DNA-binding domain of POU5F1.

2022年9月21日 · By coupling evolutionary sequence analysis with functional studies in mouse embryonic stem cells, we find that the ability of POU5 proteins to support pluripotency originated in the gnathostome...

2025年2月8日 · This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis.