Paraoxonase 1 (PON1) also known as Serum paraoxonase and arylesterase 1, A esterase, homocysteine thiolactonase or serum aryldialkylphosphatase 1, is an enzyme that in humans is encoded by the PON1 gene. [5]

Human serum paraoxonase-1 (PON1) is a calcium-dependent hydrolytic enzyme that is found in a variety of mammalian species. Abraham Mazur 1 and Norman Aldridge 2 played a pivotal role in the identification and classification of PON1 in the mid-1940s to early 1950s.

2024年12月25日 · PON1 (Paraoxonase 1) is a Protein Coding gene. Diseases associated with PON1 include Microvascular Complications Of Diabetes 5 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways …

In this review we explore the physiological roles of PON1 in disease development, as well as PON1 gene and protein structure, promiscuous activities and the roles of SNPs and ethnicity in determining PON1 activity.

Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug ...

2016年5月2日 · PON1 is a very important gene to be aware of in your Nutrition Genome Report. By focusing on nutritional ways to improve PON1 activity and avoiding ways that its function is compromised, you can strengthen your genome against …

Paraoxonase 1 (PON1) is a hydrolytic enzyme with wide range of substrates, and capability to protect against lipid oxidation. Despite of the large number of compounds that can be hydrolyzed by paraoxonase, the biologically relevant substrates are still not clearly determined.

Gene ID: 5444, updated on 8-Feb-2025. This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity.

2020年9月30日 · The PON1 gene codes for the enzyme serum paraoxonase/arylesterase 1 or PON1 that has esterase and paraoxonase activity. The PON1 enzyme is composed of 354 amino acids and is synthesized by the liver.

2021年3月24日 · We analysed the PON1 gene (PON1) polymorphisms and serum PON1 (paraoxonase) activity concerning dyslipidaemia and related cardiovascular diseases and mortality to show how they associate under...