PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene. [5] [6] It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria.

2024年12月25日 · PINK1 (PTEN Induced Kinase 1) is a Protein Coding gene. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Early-Onset Parkinson's Disease. Among its related pathways are Gene expression (Transcription) and Selective autophagy.

PINK1 is a ubiquitin and Parkin kinase (2 – 7) and functions as an early sensor and transducer of mitochondrial damage signaling (8 – 10).

2025年3月21日 · Using a high-resolution microscope to map the structure of the human version of PINK1 bound to damaged mitochondria, the researchers at the Walter and Eliza Hall Institute in Australia gained insight into the protein’s role in Parkinson’s. Understanding how PINK1 works could lead to new treatments that slow or stop the disease’s progression.

2025年3月20日 · The exact cause of Parkinson’s disease remains unknown; however, researchers know some genetic factors contribute to the condition, such as a mutation in the PINK1 gene.; A new study for the ...

2024年10月2日 · Mitophagy mediated by the recessive Parkinson’s disease genes PINK1 and Parkin responds to mitochondrial damage to preserve mitochondrial function. In the pathway, PINK1 is the damage sensor,...

2025年3月14日 · The PINK1 ubiquitin signal is unique to damaged mitochondria, and when PINK1 is mutated in patients, broken mitochondria accumulate in cells. Although PINK1 has been linked to Parkinson’s, and in particular Young Onset Parkinson’s Disease, researchers had been unable to visualise it and did not understand how it attaches to mitochondria and ...

2025年3月20日 · PINK1 is a protein linked to Parkinson’s disease, the second most common neurodegenerative disease after Alzheimer’s. There is no cure for Parkinson’s. This discovery, published in Science, is a huge leap forward in the fight against Parkinson’s with the hope that it will accelerate the search for a drug to stop the condition.

The PINK1 gene provides instructions for making a protein called PTEN induced putative kinase 1. This protein is found in cells throughout the body, with highest levels in the heart, muscles, and testes.

2 天之前 · Usually, PINK1 does a kind of scan and clear job in the body. It moves around looking for damaged mitochondria, and when it finds them, it creates a protein called ubiquitin that signals the body ...