PBRM1 is thought to be a tumor suppressor gene in many cancer subtypes largely due to the mutational pattern. [10] Most notably, mutations and copy number alterations in PBRM1 are highly prevalent in clear cell renal cell carcinoma (ccRCC).

2024年12月25日 · PBRM1 (Polybromo 1) is a Protein Coding gene. Diseases associated with PBRM1 include Clear Cell Renal Cell Carcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Gene expression (Transcription) and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding.

PBRM1 encodes the BAF180 protein, which is important in chromatin remodeling (Lu and Allis, 2017; Zhou et al., 2020). PBRM1 genes had approximately 5% mutational frequency in cancer, while with high frequency of about 20%–40% in ccRCC(15).

2020年3月16日 · Polybromo-1 (PBRM1) gene is a promising biomarker for immunotherapy in clear cell renal cell carcinoma. But to our knowledge, the frequency and clinical relevance of PBRM1 mutation in lung...

PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular landscape of PBRM1 mutated (mut) BTCs and to define potential translational aspects.

2025年1月4日 · Title: Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB.

2020年5月1日 · In this study, we found that PBRM1 loss reduced IFNγ-STAT1 signaling in murine and human RCC cell lines, respectively, in a SWI/SNF complex dependent manner. PBRM1 inactivation was associated...

2016年4月21日 · PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation of genes involved in different stages of cell division.

2019年2月26日 · Recent data suggested PBRM1 mutations may sensitize ccRCC and non RCC malignancies to ICB therapy. We queried the impact of PBRM1 loss on overall survival (OS) across 2,152 patients treated with ICB.

2021年6月1日 · Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell carcinomas (ccRCC). To identify novel therapeutic approaches to targeting PBRM1-defective cancers, we used a series of orthogonal functional genomic screens that identified PARP ...