P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial …

P-Selectin is a 140-kDa integral membrane glycoprotein that plays a role in selectin-dependent leukocyte adhesion. AI generated definition based on: Comprehensive Medicinal Chemistry III, …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. …

P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and …

2024年7月17日 · P-selectin interacts with a high affinity ligand, P-selectin glycoprotein ligand 1 (PSGL-1), expressed on the surfaces of all leukocytes, facilitating the initial “capture and …

This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.

P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression may indicate an involvement of this …

2022年5月31日 · Nature Communications - P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads …

2001年1月1日 · P-selectin (PADGEM, GMP-140, CD62) is a transmembrane protein specific to alpha granules of platelets and Weibel-Palade bodies of endotheial cells. Upon stimulation of …

2019年12月1日 · P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory …