2024年12月25日 · NR4A3 (Nuclear Receptor Subfamily 4 Group A Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include Chondrosarcoma, Extraskeletal Myxoid and Chondrosarcoma. Among its related pathways are Gene …

NR4A3 (也称为NOR-1)与NR4A1和NR4A2是组成NR4A孤儿核受体亚家族的转录因子，既往被报道作为即刻-早期反应基因调控细胞对外界刺激的反应，参与细胞增殖、分化、凋亡等重要生物学过程。 已有证据表明，NR4A受体在成骨细胞中调节成骨基因的表达和分化，且NR4A3缺乏会减少VSMCs的增殖和迁移。 因此，NR4A3可能在VSMCs表型转换和动脉中层钙化中发挥重要作用。

The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. [5] NR4A3 is a member of the nuclear receptor family of …

This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases. Keywords: NOR-1, cardiovascular remodeling, atherosclerosis, abdominal aortic aneurysm

2020年8月31日 · Nr4a1 – 3 encode a small family of orphan nuclear receptors that are rapidly induced by B cell antigen receptor stimulation. Here, we show that Nr4a1 and Nr4a3 play partially redundant roles to...

Low expression of NR4A gene family members (NR4A1, NR4A3) and 1-alpha25-dihydroxyvitamin D3 receptor (VDR) genes is demonstrated in peripheral blood mononuclear cells of multiple sclerosis patients. The pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cellular extraskeletal myxoid chondrosarcomas.

2024年6月21日 · 核受体4A3 (NR4A3，也称为NOR-1) 是载脂蛋白A-IV诱导的动脉粥样硬化进展的关键调节因子，而血管钙化和动脉粥样硬化常合并发生，但 NR4A3在血管钙化中的作用仍尚不清楚。 乳酸化修饰 是一种新型表观遗传修饰，组蛋白乳酸化可以调节基因转录，参与细胞命运决定、伤口愈合、成骨细胞分化等过程。 先前研究已经明确乳酸在VSMCs表型变化中的重要性，是刺激细胞状态转变的重要代谢物。 然而，乳酸化修饰在血管钙化的表观遗传调控作用尚未确定。

2024年1月23日 · At present, research on the role of Nr4a3 in the pathophysiology of inflammation is considerably limited, especially with respect to its role in the central nervous system (CNS). In this review, we discuss the role of Nr4a3 in multiple sclerosis, Alzheimer’s disease, retinopathy, Parkinson’s disease, and other CNS diseases.

该基因编码类固醇-甲状腺激素-类视黄醇受体超家族的成员。 编码的蛋白质可以充当转录激活剂。 该蛋白可有效结合 NGFI-B 反应元件 (NBRE) 。 三种不同版本的骨骼外粘液样软骨肉瘤 (EMC) 是该基因与其他基因相互易位的结果。 易位断点与核受体亚科 4、A 组、成员 3 (在 9 号染色体上) 和尤文肉瘤断点区域 1 (在 22 号染色体上) 、RNA 聚合酶 II、TATA 盒结合蛋白相关因子、68-KD 相关 (在 17 号染色体上) ，或转录因子 12 (在 15 号染色体上) 。 已发现该基因编码不同异构体 …

2018年11月19日 · In this study, we report an identification of NR4A3 as a direct transcriptional target of p53. Using various techniques, we showed that p53 directly bound the promoter of NR4A3 gene and induced...