2024年12月25日 · NR3C2 (Nuclear Receptor Subfamily 3 Group C Member 2) is a Protein Coding gene. Diseases associated with NR3C2 include Pseudohypoaldosteronism, Type I, Autosomal Dominant and Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy.

The NR3C2 gene provides instructions for making a protein called the mineralocorticoid receptor. This protein is important in regulating the amount of sodium in the body. Sodium regulation plays a role in blood pressure control and fluid balance.

NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation. The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian syndrome in Italian families.

Title: NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK. NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation.

NR3C2, or mineralocorticoid receptor (MR), belongs to the nuclear receptor superfamily and functions as a ligand-dependent transcription factor that mediates the effects of aldosterone on a variety of target tissues, including the distal parts of the nephron, the distal colon, the cardiovascular and central nervous systems, and brown adipose ...

NR3C2 is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

2024年5月21日 · NR3C2 is a novel potential diagnostic and prognostic biomarker and therapeutic target in NSCLC. Lung cancer is a type of malignant tumor that originates in the bronchial mucosa and alveoli. Globally, lung cancer remains the most common malignant tumor type and has a high morbidity and mortality [1].

2024年5月21日 · Two NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application potential. NR3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell infiltration.

Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy.

2024年6月19日 · Clinical resource with information about NR3C2, A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function., Autosomal dominant pseudohypoaldosteronism type 1, Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus ...