2024年12月25日 · NDN (Necdin, MAGE Family Member) is a Protein Coding gene. Diseases associated with NDN include Prader-Willi Syndrome and Schaaf-Yang Syndrome . Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System .

Necdin was originally found in 1991 as a hypothetical protein encoded by a neural differentiation‐specific gene transcript in murine embryonal carcinoma cells. Virtually all postmitotic neurons and their precursor cells express the …

Necdin is a protein that is functionally similar to Rb, but structurally different. It is a smaller protein and does not undergo posttranslational modifications. Necdin plays a role in suppressing cell growth and binds to various proteins, including the transactivation domains of E2F1 and p53.

Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly suppresses the proliferation of NIH3T3 cells. Simian virus 40 large T antigen targets both p53 and the retinoblastoma protein (Rb) for cellular transformation.

2009年1月1日 · Necdin activates GnRH through Msx/Dlx-binding sites in the GnRH enhancer and promoter regions. If necdin activates through prevention of Msx repression, the characterized Msx DNA-binding sites in the GnRH regulatory sequences should …

2011年10月27日 · Necdin expression has previously been shown to be down-regulated in a melanoma and a drug-resistant ovarian cancer cell line. Further analysis of Necdin expression demonstrated repression in a STAT3-dependent manner in human melanoma, prostate and breast cancer cell lines.

2012年2月15日 · Moreover, we established that Necdin is a negative regulator of p53-mediated growth arrest induced by nutlin-3, suggesting that Necdin upregulation could contribute to the bypass of a p53-response in p53 wild type tumors.

Necdin was originally found in 1991 as a hypothetical protein encoded by a neural differentiation-specific gene transcript in murine embryonal carcinoma cells. Virtually all postmitotic neurons and their precursor cells express the necdin gene (Ndn) during neuronal development.

2005年3月1日 · Necdin is a growth suppressor expressed predominantly in postmitotic neurons. The necdin gene is involved in the etiology of the genomic imprinting-associated neurodevelopmental disorder Prader-Willi syndrome and belongs to the MAGE gene family.

One of these genes, NDN, encodes necdin, a protein that is important for neuronal differentiation and survival. Loss of Ndn in mice causes defects in the formation and function of the nervous system. Necdin is a member of the melanoma-associated antigen gene (MAGE) protein family.