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MAP kinase kinase kinase - Wikipedia
Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, [1] MKKK, [2] M3K, [3] or, MAP3K [4]) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. …
MAPK kinase kinases (MKKKs) as a target class for small-molecule ...
2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the …
MAPK kinase kinases (MKKKs) as a target class for small ... - PubMed
Scaffolding proteins organize MKK-MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the scaffolded complex that …
Organization and regulation of mitogen-activated protein kinase ...
1999年4月1日 · MKKs are characteristically dual specificity kinases which catalyze the phosphorylation of MAPKs on both tyrosine and threonine residues. The MKKs are …
Role of mitogen-activated protein kinase kinase kinases in …
2007年5月14日 · In this review, we describe how the MKKK 'hub' function regulates the specificity of MAPK activation, highlighting MKKKs as targets for therapeutic intervention in cancer and …
Mitogen-activated protein kinase kinase - Wikipedia
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). …
MAP kinase kinase kinase kinase - Wikipedia
Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. Some signal transduction pathways. MAP4K is not labelled. MAPK …
Role of mitogen-activated protein kinase kinase kinases in signal ...
2007年5月14日 · In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs as targets for therapeutic intervention in cancer and …
signaling hubs’ that regulate the specificity of MAPK activation. In this review, we describe how the MKKK ‘hub’ function regulates the specificity of MAPK activation, highlighting MKKKs.