We maintain two views of measles evolution: The first is measles/genome, which uses full genome sequences. The second is measles/N450, which uses a 450bp region of the N gene ("N450") that is frequently sequenced for measles.

Measles is a highly contagious infectious disease caused by the measles virus, a morbillivirus in the Paramyxoviridae family of -ssRNA viruses. The disease may have existed for thousands of years. The virus was first isolated in 1954 and transformed into a vaccine in 1963 in the USA.

Wild-type measles viruses have been divided into eight clades containing 24 genotypes based on the nucleotide sequences of their hemagglutinin (H) and nucleoprotein (N) genes, which are the most variable genes in the viral genome.

Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections.

Genetic characterization of wild-type measles virus (MV) strains is a critical component of measles surveillance and molecular epidemiology. We have obtained complete genome sequences of six MV strains belonging to different genotypes, using random-primed next generation sequencing.

2014年4月17日 · Here we report the complete genome sequence of a wild-type measles virus isolated from a patient in Munich (MVi/Muenchen.DEU/19.13[D8]) during a German measles outbreak in 2013. GENOME ANNOUNCEMENT Infections caused by measles virus (MV), the prototype of the Morbillivirus genus of the Paramyxoviridae family, remain a serious threat to …

The measles virus (MV), with scientific name Morbillivirus hominis, is a single-stranded, negative-sense, enveloped, non-segmented RNA virus of the genus Morbillivirus within the family Paramyxoviridae.

Measles virus (MeV) genotype B3 is one globally significant circulating genotype. Here, we present a systematic description of long-term evolutionary characterizations of the MeV genotype B3’s hemagglutinin (H) gene in the elimination era.

The measles virus genome encodes six proteins, which are enough to choreograph its highly infectious life cycle. Three are involved in management of the genome.

2014年4月18日 · MeVs can be grouped into 24 genotypes based on the highly variable 450 nucleotides coding for the carboxyl-terminus of the nucleocapsid protein (N-450). Here, we report the genomic sequences of 2 wild-type viral isolates …

Measles virus is the prototypic member of the Morbillivirus genus of the family Paramyxoviridae. The viral genomic RNA is single-stranded, nonsegmented, and of negative polarity and encodes six major structural proteins.

Measles is one of the most infectious diseases of humans. It is caused by the measles virus (MeV) and can lead to serious illness, lifelong complications, and even death. Whole-genome sequencing (WGS) is now available to study molecular epidemiology and identify MeV transmission pathways.

The standard sequence window for measles virus is the 450-nucleotide carboxy-terminal of the nucleocapsid gene in the MeV genome; the standard sequence window for rubella virus is a 739-nucleotide fragment (nucleotides 8,731–9,469) in the E1 gene in the RuV genome.

2021年9月10日 · Molecular epidemiological investigations utilizing partial measles virus (MeV) genomes are challenged by reduction in global genotypes and low evolutionary rates. Greater resolution was reached using MeV complete genomes, however time and costs limit the application to numerous samples.

2015年4月16日 · Like many viruses, the measles virus packages its genome into capsids formed by individual proteins that self-assemble into a large three-dimensional structure. But unlike most viruses, which have rigid capsids, measles and its relatives rely on …

2025年1月15日 · The current measles epidemic in Romania is driven mainly by two D8 genotype variants with different mutation profiles and slightly different severity of the disease, highlighting the usefulness of sustained molecular surveillance. ... (HMV) strains by combining whole genome sequencing (WGS) with phylogenetic analysis, with a focus on the ...

4 天之前 · A study of six IDs (measles, mumps, chickenpox, German measles, scarlet fever, and whooping cough) conducted in 1984 on a sample of 656 twin pairs estimated heritability as 86% for measles to a 100% environmental component for scarlet fever . This study emphasizes that a genetic contribution to disease susceptibility is variable between ...

2022年6月30日 · A total of 147 complete genomes of measles virus (MV) were obtained from the laboratory-confirmed cases through Illumina MiSeq. Epidemiological, and genetic characteristics of the MV were focused on information about age, gender, immunization record, variation, and evolution of the whole genome.

We report eight near-complete genome sequences of measles virus strains from Uganda cases from 2011 to 2020, providing useful data for assessing vaccine escape and local/regional transmission.

2016年8月12日 · James and Theresa Arnold, who live on a farm near Potwin, Kansas, say that MaxMind have made their lives "digital hell," the BBC reports. The pair's home has been linked to the IP addresses because...

In this study, patients who have definite records of immunization were enrolled based on measles surveillance in Shanghai, China, from 2009 to 2017, and genomic characteristics regarding viruses retrieved from these cases provided insights into immunization failure.